Regarding the histopathological lesion, the infarct disturbed on the right side the lateral spinothalamic tract, nucleus of the spinal tract of the trigeminal nerve, spinal tract of the trigeminal nerve, spinocerebellar tract, inferior cerebellar peduncle and nucleus ambiguus.ĬONCLUSION: Based on our investigation of pathological lesions using our 2 autopsies, we suggest calling the cases that satisfy the following 3 criteria "definite pathologic Wallenberg syndrome": i) identifiable pathological obstruction of the PICA or VA ii) infarction in the lateral MO based on PICA or VA obstruction and iii) a 1-to-1 correspondence between clinical symptoms and neuropathological lesions. Lateral medullary syndrome (LMS) was first described by Gaspard Vieussux in 1808 and the first clinical description of this syndrome was given by Wallenberg in 1895. A pathological luminal occlusion was identified in the right PICA. Patient 2 showed the 3 major symptoms of right crossed sensory disturbance, right cerebellar ataxia and bulbar palsy. The left cerebellar ataxia and bulbar palsy were observed among these 3 major symptoms. (Wallenbergs Syndrome) causes the person to have balance problems and lean to one side. Moreover, a clear infarct in the left lateral MO was pathologically identified, but pathological obstruction of the left PICA or left VA could not be found. Artery (PICA) carries blood to this part of the brain. Regarding the histopathlogical distribution, the infarct extended on the right side to the lateral spinothalamic tract, nucleus of the spinal tract of the trigeminal nerve, spinal tract of the trigeminal nerve, inferior cerebellar peduncle, spinocerebellar tract and nucleus ambiguous. There was the pathological obstruction of the right vertebral artery (VA). RESULTS: Patient 1 exhibited the 3 major neurological symptoms of right crossed sensory disturbance, right cerebellar ataxia and bulbar palsy. Key Points: Lateral medullary syndrome is most commonly due to occlusion of the intracranial portion of the vertebral artery followed by PICA and its branches. METHOD: This study was carried out on brain tissue from 2 patients with typical Wallenberg syndrome and 10 autopsy cases without central nervous system disturbances. BACKGROUND: Wallenberg syndrome was first reported by Adolf Wallenberg as arising due to the obstruction of the posterior inferior cerebellar artery (PICA), which caused an infarct in the lateral medulla oblongata (MO). Le syndrome de Wallenberg ou syndrome de la fossette latérale du bulbe est une atteinte hémorragique ou ischémique du territoire vascularisé par lartère cérébelleuse postéro-inférieure (PICA).
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